The number of PON1 mutant alleles, but not PON1 phenotype, is associated with Gensini score of coronary damage
نویسندگان
چکیده
منابع مشابه
Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype.
The paraoxonase (PON1) PON1-Q192R and PON1-L55M polymorphisms have been inconsistently associated with vascular disease. Plasma PON1 activity phenotypes vary markedly within genotypes and were, therefore, expected to add to the informativeness of genotype for predicting vascular disease. The case-control sample included 212 age- and race-matched men (mean age 66.4 years). The 106 carotid artery...
متن کاملFuture studies of low-activity PON1 phenotype subjects may reveal how PON1 protects against cardiovascular disease.
The article by Jarvik et al, 1 appearing in this issue, illustrates the pros and cons of using a large panel of SNPs for probing deeper into the association between serum paraoxonase (PON1) and vascular disease. The obvious advantages of using such a series of convenient genetic markers are somewhat compromised in this instance by the presence of several, long-ago established recombination site...
متن کاملParaoxonase-1 (PON1) promoter region polymorphisms, serum PON1 status and coronary heart disease
INTRODUCTION Serum paraoxonase-1 (PON1) retards the oxidation of low-density lipoprotein and cell membranes and is atheroprotective. Polymorphisms in the promoter region of the PON1 gene have been shown to affect serum PON1 levels and have been related to the presence of coronary heart disease (CHD) in some studies. However, contradictory results have been reported with regard to promoter regio...
متن کاملThe Relationship between PON1 phenotype and PON1-192 genotype in detoxification of three oxons by human liver.
Phosphorothioate pesticides (OP) such as diazinon, chlorpyrifos, and parathion are activated to highly toxic oxon metabolites by the cytochromes P450 (P450s), mainly in the liver. Simultaneously, the P450s catalyze detoxification of OP to nontoxic dearylated metabolites. The oxon is then detoxified to the dearylated metabolite by PON1, an A-esterase present in the liver and blood serum. The aim...
متن کاملReduced serum paraoxonase 1 (PON1) activity in patients with schizophrenia treated with olanzapine but not quetiapine
BACKGROUND Second generation antipsychotics (SGAs) are currently the most prescribed drugs in the treatment of schizophrenia. Despite their advantages, which include greater improvement in negative symptoms, cognitive function, prevention of deterioration, quality of life, and fewer extrapyramidal symptoms, the concern regarding metabolic abnormalities which might cause cardiovascular diseases ...
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ژورنال
عنوان ژورنال: Romanian Review of Laboratory Medicine
سال: 2013
ISSN: 2284-5623
DOI: 10.2478/rrlm-2013-0042